Trifluoroacetic anhydride → HCID 23042861, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic anhydride (19.5 g) was added dropwise to a cooled (0° C.), stirred solution of 1-cyclopropylmethyl-1H-indole-3-carboxamide (5 g) in dioxane (100 ml) and triethylamine (18 g). After the addition the mixture was stirred at room temperature for two hours, the mixture was diluted with dichloromethane (200 ml) and washed with water (3×100 ml), dried (Na2SO4) and evaporated at reduced pressure. The residue was purified by column chromatography on silica eluting with dichloromethane to afford a colourless oil, (5 g); δH (CDCl3, 60 MHz) 0.3-0.6 (4H, m, 2×CH2), 0.9 (1H, m, CH), 4.0 (2H, d, J=7, CH2), 7.0-7.7 (5H, m); νmax 2210 (C≡N).

Provenance & Evidence