反应详情

A solution of 2.92 g of 3-amino-4-methylaminoquinoline (V-2) in 20 ml of formic acid was refluxed for 1.5 hours. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between chloroform and saturated aqueous sodium hydrogen-carbonate. The organic layer was washed with brine and dried. The chloroform was removed and the residue was crystallized from n-hexane to give 2.39 g (yield: 77%) of the titled compound (II-2). This was recrystallized from ethyl acetate to give colorless crystals melting at 146°~148° C.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was partitioned between chloroform and saturated aqueous sodium hydrogen-carbonate
3. washThe organic layer was washed with brine
4. customdried
5. customThe chloroform was removed
6. customthe residue was crystallized from n-hexane