HCID 13821494, compound → HCID 13821525, compound

HRID 2165556Notes

Reaction equation

HRID 2165556 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C@H:15]1[NH:20][C:19](=[O:21])[C@@H:18]([CH2:22][C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH3:32])[CH:24]=2)[NH:17][C:16]1=[O:33])=O)C1C=CC=CC=1>C(O)C>[NH2:11][CH2:12][CH2:13][CH2:14][C@H:15]1[NH:20][C:19](=[O:21])[C@@H:18]([CH2:22][C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH3:32])[CH:24]=2)[NH:17][C:16]1=[O:33]

Participants

3

Reactant 1

HCID 13821494HCID 13821494, compound

Product 1

HCID 13821525HCID 13821525, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of (3R,6R)-3-(3-benzyloxycarbonylaminopropyl)-6-(1-methylindol-3-ylmethyl)piperazine-2,5-dione (1.2 g) in ethanol (240 ml) containing 10% paradium on charcoal (0.6 g) was hydrogenated at ambient temperature and atmospheric pressure. After catalyst was filtered off and solvent was evaporated, crude solid was taken up with ethanol, and dried in vacuo to give (3R,6R)-3-(3-aminopropyl)-6-(1-methylindol-3-ylmethyl)piperazine-2,5-dione.

Workup

  1. customwas hydrogenated at ambient temperature
  2. filtrationAfter catalyst was filtered off
  3. customsolvent was evaporated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-c4ed992e58be4eeca674edbc29fc814a
Source dataset
uspto-grants-1990_07
Patent number
US04940709

Reaction notes

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