Water → N'-t-butyl-N-(2-thiophenecarbonyl)-N'-benzoylhydrazine

HRID 21656Notes

Reaction equation

HRID 21656 reaction equation
[C:1]([NH:5][NH:6][C:7]([C:9]1[S:10][CH:11]=[CH:12][CH:13]=1)=[O:8])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].O.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C=CC=CC=1>[C:1]([N:5]([C:17](=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[NH:6][C:7]([C:9]1[S:10][CH:11]=[CH:12][CH:13]=1)=[O:8])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 962WaterHCID 7412Benzoyl chlorideHCID 14798Sodium HydroxideHCID 15452035N'-t-butyl-N-(2-thiophenecarbonyl)hydrazine

Product 1

HCID 15452003N'-t-butyl-N-(2-thiophenecarbonyl)-N'-benzoylhydrazine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N'-t-butyl-N-(2-thiophenecarbonyl)hydrazine (1 g) was dissolved in 10 ml toluene and treated with 50% aqueous sodium hydroxide (1.0 g) and water (2 ml) followed by benzoylchloride (0.8 g). After stirring for 14 hours at room temperature, the solid product, N'-t-butyl-N-(2-thiophenecarbonyl)-N'-benzoylhydrazine, was removed by filtration and washed with water: m.p. >190° C.

Workup

  1. customthe solid product, N'-t-butyl-N-(2-thiophenecarbonyl)-N'-benzoylhydrazine, was removed by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-1a5dd7050847474898ad70b200ce4e17
Source dataset
uspto-grants-1995_06
Patent number
US05424333

Reaction notes

Loading…