反应详情

温度

130 °C

A mixture of 2 g of 2-hydroxymethylpiperazine, 1 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 8 ml of pyridine was heated at 130° C. in a sealed bottle, under argon, overnight. The solvent was removed and the residue adsorbed onto silica gel, then added to a column of flash grade silica gel. The column was eluted with methanol:water (95:5). The product fraction was collected, dissolved in methanoldichloromethane and converted to the hydrochloride salt, mp >275° C.

1. customThe solvent was removed
2. additionadded to a column of flash grade silica gel
3. washThe column was eluted with methanol:water (95:5)
4. customThe product fraction was collected
5. dissolutiondissolved in methanoldichloromethane