反应详情

温度

75 °C

A mixture of 400 mg of 2-(fluoromethyl)piperazine and 200 mg of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 3 ml of pyridine was stirred and heated at 75° C., under nitrogen, in a pressure bottle for 3 hours. The pyridine was removed and replaced with methanol. This mixture was chromatographed on silica gel, eluting with methanol:chloroform (2:8). The solid was recrystallized from methanol, giving 100 mg of the desired product, mp 177°-180° C.

1. customThe pyridine was removed
2. customThis mixture was chromatographed on silica gel
3. washeluting with methanol:chloroform (2:8)
4. customThe solid was recrystallized from methanol