Formaldehyde → HCID 14839368, compound

HRID 2165629Notes

Reaction equation

HRID 2165629 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:24])=[C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH:15]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:14]3)[CH:11]=2)[C:6](=[O:25])[C:5]([C:26]([OH:28])=[O:27])=[CH:4]1)[CH3:2].[CH2:29]=O>C(O)=O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:24])=[C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH3:29])[CH:15]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:14]3)[CH:11]=2)[C:6](=[O:25])[C:5]([C:26]([OH:28])=[O:27])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 14839367HCID 14839367, compound

Product 1

HCID 14839368HCID 14839368, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of 200 mg of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(2-thienyl)-1-piperazinyl]-3-quinolinecarboxylic acid, 0.3 ml of 37% formalin and 0.35 ml of 90% formic acid was refluxed for 2 hours, then evaporated. A 10 ml portion of water was added and the mixture neutralized with 1N sodium hydroxide. The solid was collected, washed with water, methanol, ether and dried, giving 170 mg of the desired product, mp 238°-240° C.

Workup

  1. temperaturewas refluxed for 2 hours
  2. customevaporated
  3. additionA 10 ml portion of water was added
  4. customThe solid was collected
  5. washwashed with water, methanol, ether
  6. customdried

Sources & evidence

ORD record
ord-e03cd40708e147e89bd48562eb506397
Source dataset
uspto-grants-1990_07
Patent number
US04940710

Reaction notes

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