Formic Acid → HCID 14839361, compound

HRID 2165641Notes

Reaction equation

HRID 2165641 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]3[NH:15][CH2:14][CH2:13][N:12]([C:16]4[CH:25]=[C:24]5[C:19]([C:20](=[O:31])[C:21]([C:28]([OH:30])=[O:29])=[CH:22][N:23]5[CH2:26][CH3:27])=[CH:18][C:17]=4[F:32])[CH2:11]3)=[CH:7][C:6]=2[CH:33]=1.[CH:34](O)=O>C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]3[N:15]([CH3:34])[CH2:14][CH2:13][N:12]([C:16]4[CH:25]=[C:24]5[C:19]([C:20](=[O:31])[C:21]([C:28]([OH:30])=[O:29])=[CH:22][N:23]5[CH2:26][CH3:27])=[CH:18][C:17]=4[F:32])[CH2:11]3)=[CH:7][C:6]=2[CH:33]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 14839360HCID 14839360, compound

Product 1

HCID 14839361HCID 14839361, compound

Reagents, catalysts & solvents 1

HCID 712FormaldehydeSolvent

Procedure

A 150 mg portion of 7-[3-(5-chloro-2-benzofuranyl)-1-piperazinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was suspended in 0.6 ml of 37% formaldehyde and 0.75 ml of 90% formic acid was added. The mixture was heated on a steam bath for 2 hours, then evaporated to dryness. A 5 ml portion of water was added, the pH adjusted to 7.0 with lN sodium hydroxide and the solid collected, washed with water and dried, giving 113 mg of the desired product, mp 248°-249° C.

Workup

  1. temperatureThe mixture was heated on a steam bath for 2 hours
  2. customevaporated to dryness
  3. additionA 5 ml portion of water was added
  4. customthe solid collected
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-d38fcbb4f54c4bd382cc152d828a5ba9
Source dataset
uspto-grants-1990_07
Patent number
US04940710

Reaction notes

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