HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-Ethyl-6-fluoro-1,4-dihydro-7-[3-(1H-indol-3-yl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 19763607 | HCID 19763607 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Ethyl-6-fluoro-1,4-dihydro-7-[3-(1H-indol-3-yl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 14839386 | 64.5% |
Reaction Steps
A mixture of 574 mg of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-[1-(phenylsulfonyl)-1H-indol-3-yl]-1-piperazinyl]-3-quinolinecarboxylic acid, 10 ml of 1N sodium hydroxide and 20 ml of dioxane was reacted as described in Example 56, giving 280 mg of the desired product, mp 230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04940710 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-4aafc676e13a44559dcd2b245d9f13ff |
| Source note | uspto-grants-1990_07 |