反应详情

温度

80 °C

A mixture of 2 g of 2-[(1-methylethoxy)methyl]-piperazine, 1.27 g of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 5 ml of pyridine was heated at 80° C. for 3 hours, then evaporated in vacuo. The residue was reevaporated three times from toluene, giving a gum. Ether was added to the gum which solidified. The solid was triturated with ether containing methanol and then dried giving 2.1 g of solid. A 1 g portion was purified by chromatography, giving 650 mg of the desired product, mp 144°-146° C.

1. customevaporated in vacuo
2. customThe residue was reevaporated three times from toluene
3. customgiving a gum
4. customThe solid was triturated with ether
5. additioncontaining methanol
6. customdried