HRID2165658

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID712

Formaldehyde

CH2O

结构：CCCCCCCCCCCCOCC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CC)CCN1

HCID14839390

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCOCC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CC)CCN1C

HCID14839391

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID284

Formic acid

CH2O2

PROCEDURE

实验过程

A 300 mg portion of 7-[3-[(dodecyloxy)methyl]-1-piperazinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was dissolved in a mixture of 1.2 ml of 37% formaldehyde and 1.5 ml of 90% formic acid, heated on a steam bath for 45 minutes and then evaporated in vacuo. A 5 ml portion of water was added, the solution neutralized with aqueous sodium hydroxide and the solid collected, washed with water and dried, giving 260 mg of the desired product, mp 166°-168° C.

WORKUP

后处理

temperatureheated on a steam bath for 45 minutes
customevaporated in vacuo
additionA 5 ml portion of water was added
customthe solid collected
washwashed with water
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d7602fe279e344c085c32a6911811770
来源数据集: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04940710
来源说明: uspto-grants-1990_07

反应 SMILES

[CH2:1]([O:13][CH2:14][CH:15]1[NH:20][CH2:19][CH2:18][N:17]([C:21]2[CH:30]=[C:29]3[C:24]([C:25](=[O:36])[C:26]([C:33]([OH:35])=[O:34])=[CH:27][N:28]3[CH2:31][CH3:32])=[CH:23][C:22]=2[F:37])[CH2:16]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH2:38]=O>C(O)=O>[CH2:1]([O:13][CH2:14][CH:15]1[N:20]([CH3:38])[CH2:19][CH2:18][N:17]([C:21]2[CH:30]=[C:29]3[C:24]([C:25](=[O:36])[C:26]([C:33]([OH:35])=[O:34])=[CH:27][N:28]3[CH2:31][CH3:32])=[CH:23][C:22]=2[F:37])[CH2:16]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]