HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid → 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 57338 | — |
| Reactant | 2-(Methoxymethyl)piperazine | HCID 14230264 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 14839406 | — |
Reaction Steps
A 906 mg portion of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine were added to 10 ml of pyridine and reacted as described in Example 81, giving 187 mg of the desired product, mp 216°-218° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04940710 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-8125365767bf4ef0b61cfafca36f90ea |
| Source note | uspto-grants-1990_07 |