反应详情

温度

120 °C

A mixture of 365 mg of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 593 mg of 3-(3-furanyl)piperazine and 10 ml of pyridine was heated in a pressure bottle at about 120° C. for 2 days, then allowed to cool and the solvent removed. The residue was purified by flash silica gel column chormatography eluting with chloroform:methanol:water:triethylamine (95:5:1:1). This product was then triturated with methanol-ether and the solid, washed with methanol, then ether and dried in vacuo, giving 125 mg of the desired product, mp 202°-204° C.

1. temperatureto cool
2. customthe solvent removed
3. customThe residue was purified by flash silica gel column chormatography
4. washeluting with chloroform:methanol:water:triethylamine (95:5:1:1)
5. customThis product was then triturated with methanol-ether
6. washthe solid, washed with methanol
7. dry with materialether and dried in vacuo