HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → (+)-1-Ethyl-6,8-difluoro-7-[3-(fluoromethyl)-4-methyl-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | (+)-1-Ethyl-6,8-difluoro-7-[3-(fluoromethyl)-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 14839398 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | (+)-1-Ethyl-6,8-difluoro-7-[3-(fluoromethyl)-4-methyl-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 14839399 | 70.7% |
Reaction Steps
A mixture of 150 mg of (-)-1-ethyl-6,8-difluoro-7-[3-(fluoromethyl)-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (Ex. 64) was reacted as described previously with 400 mg of sodium acetate, 3 ml of formic acid and 3 ml of formaldehyde, giving 110 mg of the desired product, mp 208°-210° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04940710 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-1274e175a5c8416b8b8a3d24a01be728 |
| Source note | uspto-grants-1990_07 |