HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1,1-Difluoroethyl)pyrazine → 2-(1,1-Difluoroethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1,1-Difluoroethyl)pyrazine | HCID 19763564 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(1,1-Difluoroethyl)piperazine | HCID 19763581 | — |
Reaction Steps
A 4.3 g portion of 3-(1,1-difluoroethyl)pyrazine in 25 ml of methanol was reduced with 50 psi hydrogen and 750 mg of platinum oxide at 20° C. for 5 hours. The resulting oil was purified by chromatography, giving about 700 mg of 3-(1,1-difluoroethyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04940710 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-7053e119313444eda8d7a9bd2c4a6746 |
| Source note | uspto-grants-1990_07 |