HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2165693Generated: October 30, 2026
Fluoroquinolonic acid → HCID 23042979, compound
https://huagongshe.com/reaction/2165693
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Fluoroquinolonic acid | HCID 483180 | — |
| Reactant | 2-Pyridin-3-yl-piperazine | HCID 3872289 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 23042979 | HCID 23042979 | 19.6% |
Reaction Steps
A mixture of 733.5 mg of 2-(3-pyridinyl)piperazine, 421.5 mg of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 10 ml of pyridine was heated at 135° C. for 24 hours. The solvent was removed and the residue purified by chromatography on silica gel using chloroform:methanol:triethylamine:water (9.5:0.5:0.01:0.01), giving 120 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04940710 |
|---|
| Source dataset | uspto-grants-1990_07 |
|---|
| ORD ID | ord-c17d476939414631be7f092d29409b9b |
|---|
| Source note | uspto-grants-1990_07 |
|---|
