Water → Ethyl 2,4,5-trifluorobenzoylacetate
Reaction equation
[F:1][C:2]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].O>O1CCOCC1>[F:1][C:2]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:3]=1[C:4](=[O:5])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 102 °C
Procedure
A solution of 23.8 g of (2,4,5-trifluorobenzoyl)propanedioic acid, diethyl ester, 2.7 ml of water and 740 ml of p-dioxane was placed in an oil bath and stirred at 102° C. for 7 hours. The solution was then evaporated to dryness, heptane was added and the mixture refrigerated overnight. The resulting crystals were collected, washed with 10 ml of cold heptane and dried, giving 10.8 g of 2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester.
Workup
- customThe solution was then evaporated to dryness, heptane
- additionwas added
- customthe mixture refrigerated overnight
- customThe resulting crystals were collected
- washwashed with 10 ml of cold heptane
- customdried
Sources & evidence
- ORD record
- ord-704dd9cf984647e7961877b5a76cdca2
- Source dataset
- uspto-grants-1990_07
- Patent number
- US04940710
Reaction notes
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