関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 反応物 | Ethyl 3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)propanoate | HCID 54008204 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | HCID 178471873 | HCID 178471873 | — |
反応手順
A solution of 9.67 g of α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester in 70 ml of dry ether was cooled in an ice bath to 10° C. A 2.44 ml portion of cyclopropylamine was added dropwise, maintaining the reaction temperature at 10 to 11° C. When addition was complete the ice bath was removed, the mixture stirred at room temperature for 10 minutes and then evaporated, giving 10.02 g of α-[(cyclopropylamino)methylene]2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04940710 |
|---|
| 出典データセット | uspto-grants-1990_07 |
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| ORD ID | ord-e3434c40840c42f5a52e4f8c24cb981a |
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| 出典メモ | uspto-grants-1990_07 |
|---|
