HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2165704Generated: November 1, 2026
Ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate → 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
https://huagongshe.com/reaction/2165704
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 9817544 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | 95.9% |
Reaction Steps
A suspension of 7.85 g of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ethyl ester in 220 ml of 2N sulfuric acid was heated at 100° C. overnight, then cooled in an ice bath. The solid was collected, washed with water and dried, giving 6.81 g of the desired compound, mp 292°-293° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04940710 |
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| Source dataset | uspto-grants-1990_07 |
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| ORD ID | ord-bbb5d0e35f564309969b6cb210aa8bc5 |
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| Source note | uspto-grants-1990_07 |
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