HCID 136109365, compound → HCID 135578121, compound

Participants

Reaction Steps

A solution of 3-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propionaldehyde diethyl acetal (30.0 g, 78.5 mmol) in distilled water (600 ml) was stirred at 53° C. for 3.5 hours and spin evaporated in vacuo at 45° C. The residue was dissolved in dichloromethane (750 ml), washed with brine (50 ml), dried (MgSO4), and spin evaporated in vacuo to a dry solid. Recrystallization from acetone gave 16.23 g (67% of theory) of 3-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propionaldehyde, mp 164°-168° C., which was identical to that prepared by Method 1.

Provenance & Evidence