Ethyl Acetate → HCID 136404501, compound

Participants

Reaction Conditions

Reaction Steps

196.4 g (0.6 mol) of 2-bromo-1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone from step (a) and 59.6 g (0.5 mol) of 4,4-dimethylthiosemicarbazide were suspended in 1500 ml of ethanol and slowly heated to 70° C. while stirring, a clear solution being produced. The solution was stirred at this temperature for 10 minutes and then cooled, and the solvent was removed under reduced pressure. Washing the residue, produced as an oil, by stirring with 500 ml of ethyl acetate produced a batch of crystals, which was again briefly heated to boiling in 500 ml of ethyl ester. The crystalline product was filtered off, washed with 150 ml of ethyl acetate and dried in a vacuum cabinet.

Provenance & Evidence