Bromine → 1-Bromo-4-(4-chlorophenyl)-3,3-dimethylbutan-2-one

HRID 2165748Notes

Reaction equation

HRID 2165748 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([CH3:16])([CH3:15])[C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=1>C(Cl)(Cl)Cl>[Br:1][CH2:13][C:12](=[O:14])[C:11]([CH3:16])([CH3:15])[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 128706324-(4-Chlorophenyl)-3,3-dimethylbutan-2-one

Product 1

HCID 132865251-Bromo-4-(4-chlorophenyl)-3,3-dimethylbutan-2-oneYield 100.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

98.8 g (0.6 mol) of bromine are added dropwise to 130 g (0.62 mol) of 1-(4-chlorophenyl)-2,2-dimethyl-3-butanone in 1000 ml of chloroform at room temperature. The reaction mixture is subsequently stirred for 1 hour and is then concentrated. 174.7 g (97.3% of theory) of 4-bromo-1-(4-chlorophenyl)-2,2-dimethyl-3-butanone of refractive index nD20 1.5570 are obtained.

Workup

  1. concentrationis then concentrated

Sources & evidence

ORD record
ord-390ec85dd9264dc3b93301b2f2b9767f
Source dataset
uspto-grants-1990_07
Patent number
US04940798

Reaction notes

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