3-Furanol, tetrahydro- → HCID 23042358, compound

HRID 2165798Notes

Reaction equation

HRID 2165798 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])[N:14]([CH3:26])[C:13]2=[O:27])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O:28]1[CH2:32][CH2:31][CH:30](O)[CH2:29]1>>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:24])([F:25])[C:20]([F:23])([F:21])[F:22])[N:14]([CH3:26])[C:13]2=[O:27])=[CH:7][C:3]=1[C:4]([O:6][CH:30]1[CH2:31][CH2:32][O:28][CH2:29]1)=[O:5]

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 19832683HCID 19832683, compound

Product 1

HCID 23042358HCID 23042358, compound

Procedure

In an analogous manner, starting from 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-pentafluoroethyl-1(2H)-pyrimidinyl]-4-fluorobenzoic acid via its acid chloride and tetrahydrofuran-3-ol there is obtained 3-tetrahydrofuryl 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-pentafluoroethyl-1(2H)-pyrimidinyl]-4-fluorobenzoate, 1H-NMR (D6 -DMSO, 400 MHz): 2.00-2.09 (m, 1H), 2.20-2.32 (m,1H), 3.43 (s,3H), 3.74-3.92 (m,4H), 5.48-5.56 (m,1H), 6.50 (s,1H), 7.89 (d,1H), 8.08 (d,1H);

Sources & evidence

ORD record
ord-d38cc1ba8f6a4f1aa26eff4ece479d5e
Source dataset
uspto-grants-1990_07
Patent number
US04941909

Reaction notes

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