Dichloromethane → HCID 14324551, compound

Participants

Reaction Conditions

Reaction Steps

1 liter of dichloromethane was added to 800 g of 4 chloro-3-nitrobenzenesulfonyl chloride and cooled to 0° C. To the solution was added dropwise a mixture comprising 600 g of hexadecylamine, 251 ml of triethylamine and 780 ml of dichloromethane at 20 to 30° C. After being reacted for 2 hours at room temperature, the dichloromethane was removed by distillation under reduced pressure, and 3 liters of methanol was added to the residue and dissolved under heat. The resulting solution was gradually cooled and crystallized out at room temperature. Further, 3 liters of methanol was added and the resulting solution was again crystallized out under ice-cooling, and the crystal precipitated was taken out by filtration and dried. Yield: 1020 g, 88%.

Provenance & Evidence