1-(6-Bromohexyloxy)-4-methoxybenzene → 7-Hexyl-1-[6-(4-methoxyphenoxy)hexyl]-3-methylxanthine

HRID 2165817Notes

Reaction equation

HRID 2165817 reaction equation
[CH2:1]([N:7]1[C:15]2[C:14](=[O:16])[NH:13][C:12](=[O:17])[N:11]([CH3:18])[C:10]=2[N:9]=[CH:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH3:19][O:20][C:21]1[CH:34]=[CH:33][C:24]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br)=[CH:23][CH:22]=1>>[CH2:1]([N:7]1[C:15]2[C:14](=[O:16])[N:13]([CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][O:25][C:24]3[CH:33]=[CH:34][C:21]([O:20][CH3:19])=[CH:22][CH:23]=3)[C:12](=[O:17])[N:11]([CH3:18])[C:10]=2[N:9]=[CH:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 20636701-(6-Bromohexyloxy)-4-methoxybenzeneHCID 42536707-Hexyl-3-Methylxanthine

Product 1

HCID 217698417-Hexyl-1-[6-(4-methoxyphenoxy)hexyl]-3-methylxanthineYield 71%

Procedure

7-Hexyl-3-Methylxanthine and 6-(4-methoxyphenoxy)hexyl bromide were reacted and treated in substantially the same manner as described in Example 9 (a) to give 7-hexyl-1-[6-(4-methoxyphenoxy)hexyl]-3-methylxanthine (71%) as an oil.

Workup

  1. additiontreated in substantially the same manner

Sources & evidence

ORD record
ord-cb06825407e5410ca7e5e66afb3c8152
Source dataset
uspto-grants-1990_07
Patent number
US04942143

Reaction notes

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