Ammonia → HCID 136404505, compound

Participants

Reaction Steps

9-(4-Hydroxy-3-hydroxymethylbut-1-yl)guanine (3.0 g) was suspended in water (150 ml) and concentrated aqueous ammonia was added until complete dissolution occurred. The solution was allowed to stand in a well ventilated place for 44 h and was then filtered to afford large clear crystals of 9-(4-hydroxy-3-hydroxymethylbut-1yl)guanine monohydrate (2.08 g). Found: C, 44.09; H, 6.33; N, 25.72%. C10H15N5O3.H2O requires C, 44.28; H, 6.32; N, 25.82%. The mother liquor was left for a further 68 h (final pH=9.0) and filtered to give small clear crystals of 9-(4-hydroxy-3-hydroxymethylbut-1yl)guanine monohydrate (0.83 g). Found: C, 44.29; H, 6.27; N, 25.83%. C10H15N5O3.H2O requires C, 44.28; H, 6.32; N, 25.82%. Total 2.91 g, 91%.

Provenance & Evidence