Carbon Dioxide → HCID 136404505, compound

Participants

Reaction Steps

9-(4-Hydroxy-3-hydroxymethylbut-1-yl)guanine (3.0 g) was suspended in water (120 ml) and sodium hydroxide (4.8 g) was added. When complete dissolution had occurred, a stream of air containing carbon dioxide was bubbled through the solution. When the solution started to become cloudy the air flow was stopped and a flocculent white precipitate rapidly appeared. On standing overnight (solution pH=10.5) the precipitate recrystallised and the solution was filtered to afford clear crystals of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine monohydrate (2.5 g, 78%). Found: C, 43.56; H, 6.21; N, 25.40%. C10H15N5O3.H2O requires C, 44.28; H, 6.32; N, 25.82%. Thermogravimetric analysis, found: 6.75% weight loss (90-150° C.); theory for loss of H2O from C10H15N5O3.H2O: 6.64% weight loss.

Provenance & Evidence