HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 3-Bromo-N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-[(2-Methylquinolin-4-yl)amino]propane-1,2-diol | HCID 14209231 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Bromo-N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine | HCID 14209241 | — |
Reaction Steps
Bromine (33.7 g) was added dropwise to a solution of 49 g of N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine in 600 ml of acetic acid. After two hours of stirring, the resultant oil was separated by decantation, dissolved in 500 ml of water and the mixture made alkaline (pH=10) with potassium carbonate. The resultant free base solid was filtered and recrystallized from ethanol. The yield was 33 g, mp 140°-141° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04942168 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-83eb8e73895b40bc8841848be1bc6e8c |
| Source note | uspto-grants-1990_07 |