HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-chloroquinoline → HCID 14209243, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-chloroquinoline | HCID 618306 | — |
| Reactant | Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1) | HCID 3084332 | — |
| Reactant | 1-Ethoxyethanol | HCID 10129898 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 14209243 | HCID 14209243 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 3-bromo-4-chloroquinoline (12.1 g), 1-aminomethyl-1-cyclohexanol HCl (8.3 g), triethylamine (7.2 g) and 30 ml of ethoxyethanol was stirred at 120° C. for 5 hours and poured into 250 ml of ice water. The solid was filtered and recrystallized from acetone. The yield was 6.5 g, mp 130°-132° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04942168 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-4f7b7501b804427d8838d00b4f6b6a89 |
| Source note | uspto-grants-1990_07 |