N-Ethylethylenediamine → HCID 13908289, compound

HRID 2165891Notes

Reaction equation

HRID 2165891 reaction equation
O.[C:2]([OH:6])(=[O:5])[CH:3]=O.[CH2:7]([NH:9][CH2:10][CH2:11][NH2:12])[CH3:8].[H][H]>C(O)C.[Pd]>[CH2:7]([NH:9][CH2:10][CH2:11][NH:12][CH2:3][C:2]([OH:6])=[O:5])[CH3:8]

Participants

6

Reactant 3

HCID 66071N-EthylethylenediamineHCID 15620607Glyoxylic acid, monohydrateHCID 178418361HCID 178418361, compound

Product 1

HCID 13908289HCID 13908289, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of glyoxylic acid hydrate (9.2 g, 0.10 mol) and N-ethylethylenediamine (8.82 g, 0.10 mol) in ethanol (150 ml) was hydrogenated in a Paar apparatus at 20°-25° and an initial pressure of 51 psi with 5% Pd on carbon (2.0 g) as catalyst. After 18 hours, hydrogen uptake was complete. Catalyst was removed by filtration through a pad of diatomaceous earth and the filtrate concentrated to give N-(2-ethylaminoethyl)glycine.

Workup

  1. customwas hydrogenated in a Paar apparatus at 20°-25°
  2. customCatalyst was removed by filtration through a pad of diatomaceous earth
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-1ea99d33b2e9466aa2fc2f921b05fcfe
Source dataset
uspto-grants-1990_07
Patent number
US04942226

Reaction notes

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