HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 2-Amino-3-(5-methoxy-3-indolyl)-propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 2-(5-methoxy-1H-indol-3-yl)acetonitrile | HCID 3564783 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Amino-3-(5-methoxy-3-indolyl)-propionitrile | HCID 19901180 | 43% |
Reaction Steps
Using the same method starting from 5.4 millimoles (1 g) of (5-methoxy-3-indolyl)-acetonitrile and replacing of cyanising agent by 20 ml of a normal solution of sodium cyanide in dimethylformamide, there are obtained, after purification by an acid-base extraction, 0.50 g of 2-amino-3-(5-methoxy-3-indolyl)-propionitrile with a yield of 43%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04942221 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-3cd9ff2b357c4ef9b1b83b9fe51cc901 |
| Source note | uspto-grants-1990_07 |