Barbituric Acid → HCID 178514329, compound

Participants

Reaction Conditions

Reaction Steps

29.9 g (0.22 mol) of aminoguanidine bicarbonate are dissolved in a mixture of 150 ml of water and 54 ml of 10N hydrochloric acid, and the solution is cooled to 0° C. by adding ice. 50 ml of an aqueous solution of sodium nitrite containing 30 g of dissolved sodium nitrite per 100 ml are added dropwise to this mixture in the course of about 15 minutes. After 5 minutes, a nitrite excess which may be present is removed using amidosulphonic acid. 25.6 g (0.2 mol) of barbituric acid are thrown into the solution of azidoformamidinium hydrochloride thus obtained, and the mixture is heated at 70° C. for 4 hours and at 95° for 1 hour. The solution is then cooled down to 0°-5°, the precipitate is filtered off with suction and washed with ice-cold water. Drying at 70° in a through-circulation cabinet gives 27.8 g (90.2%) of diazobarbituric acid of the formula ##STR8##

Provenance & Evidence