化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → 3,5-Dimethyl-4-(3-ethynylpropoxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 3,5-dimethyl-4-(3-ethynylpropoxy)benzoate | HCID 15057290 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3,5-Dimethyl-4-(3-ethynylpropoxy)benzoic acid | HCID 15057291 | 71.2% |
反応手順
The ethyl ester of part (a) (7.4 g) was hydrolyzed, first with 0.9 g lithium hydroxide in 25 ml methanol and 10 ml water, stirred at room temperature for 3 days, and then with 50 ml 10% sodium hydroxide in 100 ml ethanol, heated at reflux for 2 hrs. The product was isolated by acidification, extraction with ether and concentration to give 4.7 g 3,5-dimethyl-4-(3-ethynylpropoxy)benzoic acid, m.p. 129°-130° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04942241 |
| 出典データセット | uspto-grants-1990_07 |
| ORD ID | ord-9bf0ee4cf8d4410f82527c5185c46f2b |
| 出典メモ | uspto-grants-1990_07 |