HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrophenol → 4-[(2-Nitrophenoxy)methyl]-2-phenylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrophenol | HCID 6947 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-(Chloromethyl)-2-phenyl-1,3-thiazole hydrochloride | HCID 16243675 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-[(2-Nitrophenoxy)methyl]-2-phenylthiazole | HCID 4794620 | 67% |
Reaction Steps
To a solution of 10.7 g (0.08 mol) of 2-nitrophenol in 500 ml of acetone are added 19.0 g (0.08 mol) of 4-chloromethyl-2-phenylthiazole hydrochloride, 26.3 g (0.08 mol) of cesium carbonate, and 0.5 g of potassium iodide, and the slurry is heated to reflux for 20 hours. The mixture is filtered, and the filtrate is concentrated in vacuo to obtain a crystalline residue. Recrystallization from ethanol gives 16.7 g (67%) of crystals, m.p. 95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04942236 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-01e47a76e6304d298a6a4ddaf29fc147 |
| Source note | uspto-grants-1990_07 |