HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 3-(2-Phenyl-4-thiazolylmethoxy)benzenacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-(3-Hydroxyphenyl)acetonitrile | HCID 13781042 | — |
| Reactant | 4-(Chloromethyl)-2-phenyl-1,3-thiazole hydrochloride | HCID 16243675 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-(2-Phenyl-4-thiazolylmethoxy)benzenacetonitrile | HCID 14479985 | 43.5% |
Reaction Steps
To a solution of 14.0 g (0.105 mol) of 3-hydroxyphenylacetonitrile in 500 ml of acetone were added 25.9 g (0.105 mol) of 4-chloromethyl-2-phenylthiazole hydrochloride and 34.2 g (0.105 mol) of cesium carbonate and 1 g of potassium iodide and the slurry is heated to reflux for 20 hours. The mixture is filtered and the solution is concentrated in vacuo to obtain crystals. Recrystallization from ethyl acetate gives 14.0 g (43%) crystals, m.p. 108°-110° C. The product is used without further purification in subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04942236 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-9356721169b84a5aa8552ca440955244 |
| Source note | uspto-grants-1990_07 |