Hydrochloric Acid → HCID 14832881, compound

Participants

Reaction Steps

63 mmol (100 ml of ether solution) of C8H17MgBr were added in a nitrogen atmosphere to a ether solution (150 ml) containing 10 g of Compound 1 and 1.25 g of dichloro[1,3-bis(diphenylphosphine)propane]nickel, and refluxed for 20 hours. After cooling down, 800 ml each of dichloromethane and 1M hydrochloric acid were added to obtain an oily reaction product by extraction. By purifying the above reaction product with column chromatography (silica gel, petroleum ether/ethyl ether), 8.1 g of pure 6,6'-dioctyl-2,2'-dimethoxy-1,1'-binaphthyl (Compound 2) were obtained (yield: 72%).

Provenance & Evidence