Potassium Hydroxide → HCID 178448011, compound

Participants

Reaction Steps

A solution of 6.5 g of 3-[trans-4-(trans-4-n-propyl-cyclohexyl)-cyclohexyl]-cyclohex-2-enone [m.p. 96.5°; obtainable by reacting trans-4-(trans-4-n-propycyclohexyl)-acetylcyclohexane with LDA/ether at -85°, adding 1-(trimethylsilyl)-vinyl methyl ketone at -95°, allowing the mixture to warm up to room temperature, adding methanolic KOH and working up in the customary manner (silica gel; 5:3.5:1.5 petroleum ether:methylene chloride:ether)] in 210 ml of ethanol is added to a suspension of 1.7 g of 5% Pd/CaCO3 in 75 ml of ethanol, and the mixture is stirred under hydrogen for 2 hours. Removing the catalyst and working up in the customary manner gives 3-[trans-4-(trans-4-n-propylcyclohexyl)-cyclohexyl]-cyclohexanone, m.p. 1.5°, c.p. 158.2°

Provenance & Evidence