Acetylthiourea → HCID 13922713, compound

Participants

Reaction Conditions

Reaction Steps

The crude product of a 2.2 mol batch of tert.-butyl 4-chloro-2-ethylidene-3-oxobutyrate, dissolved in 100 ml of dimethylformamide, is added to a solution, warmed to 85° C., of 236 g (2 mol) of acetylthiourea in a mixture of 360 ml of water and 720 ml of dimethylformamide. The mixture is stirred at 85° C. for two hours and concentrated, the residue is taken up in ethyl acetate and the solution is extracted three times with water. After drying and concentrating, by-products are precipitated with ether.

Provenance & Evidence