1-(Thiophen-3-ylmethyl)piperazine → 1-[4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yloxy)-1-oxobutyl]-4-(3-thienylmethyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(Thiophen-3-ylmethyl)piperazine	HCID 3494696	—
Reactant	4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid	HCID 14280990	—
Product	1-[4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yloxy)-1-oxobutyl]-4-(3-thienylmethyl)piperazine	HCID 15005631	—

Reaction Steps

Reaction of N-(3-thienylmethyl)piperazine and 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butyric acid (2g) analogously to the procedure of Example 4 gave the title compound after crystallization from methanol/diethyl ether as the dihydrochloride salt; yield 3.35 g (91%), m.p. indistinct, decomposed at 245°-250° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04943573
Source dataset	uspto-grants-1990_07
ORD ID	ord-496c6f4b0ad64cec8467b70e6ae8c920
Source note	uspto-grants-1990_07