反应详情

A mixture of 50 parts of 4-chloro-3-nitrobenzoic acid and 222 parts of 1-butanamine was stirred for 3 hours at reflux temperature. After cooling and evaporation of the excess of 1-butanamine, the reaction mixture was acidified with a sulfuric acid solution 2N to pH 1. The precipitated product was filtered off and dried, yielding 59 parts (100%) of 4-(butylamino)-3-nitrobenzoic acid (int. 7).

1. temperatureat reflux temperature
2. temperatureAfter cooling
3. customevaporation of the excess of 1-butanamine
4. filtrationThe precipitated product was filtered off
5. customdried