Dimethylformamide → HCID 23042161, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 8.83 g of 4-phenoxyphenol in 15 ml of absolute dimethylformamide is dripped into 1.5 g of 80% strength sodium hydride in 15 ml of absolute dimethylformamide. Upon completion of hydrogen evolution, 7.0 g of 4-chloromethyl-2-methylthiazole is dripped in and the mixture stirred for 3 hours at 80° C. After the solvent has been removed, the residue is slurried with 200 ml of water and extracted 3 times, each time with 50 ml of ether. After drying over sodium sulfate and removal of the solvent, the crude product is recrystallized from cyclohexane/methyl tert-butyl ether (20:1). There is obtained 6.5 g of 2-methyl-4-[(phenoxyphenoxy)-methyl]-thiazole; m.p.: 70°-73° C.

Provenance & Evidence