Dimethylformamide → HCID 15718907, compound

Participants

Reaction Steps

A mixture of 4.53 parts of chloroacetonitrile, 17.3 parts of 3-(2-ethoxyethyl)-2-(4-piperidinylmethyl)-3H-imidazo[4,5-b]pyridine, 6 parts of N,N-diethylethanamine and 94 parts of N,N-dimethylformamide was stirred for 3 hours at room temperature. The reaction mixture was poured into water and the product was extracted with 1,1'-oxybisethane. The extract was dried, filtered and evaporated, yielding 23.75 parts (100%) of 4-[[3-(2-ethoxyethyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl]-1-piperidineacetonitrile as a residue (compound 104).

Provenance & Evidence