p-Fluoronitrobenzene → HCID 59189900, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-aminoindole-3-carboxamide (Reference compound 18-1, 0.20 g, 1.1 mmol) in anhydrous N,N-dimethylformamide (2 mL) and a solution of 4-fluoronitrobenzene (0.13 mL, 1.3 mmol) in anhydrous N,N-dimethylformamide (2 mL) were successively added to a suspension of sodium hydride (purity 60%, g, 1.3 mmol) in anhydrous N,N-dimethylformamide (3 mL) under ice-cooling, and the mixture was stirred at 85° C. for 3 hours. The reaction mixture was poured into ice-water (20 mL), the precipitated solid was washed with ethyl acetate (4 mL). The resultant solid was dried under reduced pressure to give the title reference compound (0.087 g) as a brown solid (yield 26%).

Provenance & Evidence