HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 2-(4-Morpholinophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Bis(2-chloroethyl) ether | HCID 8115 | — |
| Reactant | 4-Aminophenethyl alcohol | HCID 66904 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Morpholinophenyl)ethanol | HCID 13592803 | 58% |
Reaction Steps
4-Aminobenzeneethanol (20.2 g), 2-chloroethyl ether (21.1 g), N,N-diisopropylethylamine (38.1 g) and potassium iodide (48.8 g) in DMF were heated to 80° under nitrogen for 60 h. The solvent was evaporated and the residue (~143 g) was purified by FCC eluting with ER-CX (1:1→1:0) to give the title compound as a pink-white solid (17.7 g) m.p. 57°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04943591 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-d07af3a591da4c4198bfa5cbe1238b03 |
| Source note | uspto-grants-1990_07 |