反应详情

A mixture of 4-methoxybenzeneethanol (7.0 g), 1,5-dibromopentane (20 ml), 50% aqueous sodium hydroxide (30 ml) and tetrabutylammonium bisulphate (1 g) was stirred at room temperature overnight, water (100 ml) was added and the mixture was extracted with ER (2×100 ml). The organic extracts were washed with water and brine, dried and concentrated in vacuo to give an oil which was purified by FCC eluting with hexane→hexane-ER (9:1) to give the title compound as a colourless liquid (10.5 g). T.l.c. hexane-ER (9:1) Rf 0.28.

1. extractionthe mixture was extracted with ER (2×100 ml)
2. washThe organic extracts were washed with water and brine
3. customdried
4. concentrationconcentrated in vacuo
5. customto give an oil which
6. customwas purified by FCC
7. washeluting with hexane→hexane-ER (9:1)