HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → ethyl (S)-4-[[1-(aminocarbonyl)propyl]amino]butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | (2S)-2-Aminobutanamide hydrochloride | HCID 11961924 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | ethyl (S)-4-[[1-(aminocarbonyl)propyl]amino]butyrate | HCID 29938336 | — |
Reaction Steps
143.6 ml (1.035 mole) of triethylamine are added to a suspension of 47.75 g (0.345 mole) of (S)-2-amino-butanamide hydrochloride ([alpha]D25 : +26.1°; c=1, methanol) in 400 ml of toluene. The mixture is heated to 80° and 67.2 g (0.345 mole) of ethyl 4-bromobutyrate are introduced dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04943639 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-e39aa21257634fde864d9cfc4d985b46 |
| Source note | uspto-grants-1990_07 |