2-Anilino-4-methyl-6-(2-chloropropen-1-yl)pyrimidine → Mepanipyrim

Participants

Reaction Steps

Into a 50 ml round bottom flask, 0.52 g (0.02 mol) of 2-anilino-4-methyl-6-(2-chloropropen-1-yl)pyrimidine, 4.0 g of KF/alumina and 20 ml of anhydrous acetonitrile were charged, and the mixture was stirred at room temperature for 5 hours in the flask equipped with a calcium chloride tube. Then, the mixture was subjected to filtration to remove the solid content, and the solvent was distilled off. The residue was dissolved in toluene and washed with water. This toluene layer was washed with water and concentrated, and then it was subjected to column chromatography to obtain 0.3 g of 2-anilino-4-methyl-6(1-propynyl)pyrimidine having a melting point of from 125° to 126° C. The yield was 67%.

Provenance & Evidence