tert-Butanol → Mepanipyrim

Participants

Reaction Conditions

Reaction Steps

Into a 100 ml reaction flask equipped with a stirrer and a thermometer, 5.2 g (0.02 mol) of 2-anilino-4-methyl-6-(2-chloropropen-1-yl)pyrimidine and 40 ml of t-butanol were charged, and the mixture was heated to 60° C. Then, 4.49 g (0.08 mol) of potassium hydroxide powder was added thereto, and the mixture was reacted for 6 hours. After completion of the reaction, the mixture was put into water and extracted with toluene. The toluene layer was washed with water and concentrated, and then it was subjected to column chromatography to obtain 2.48 g of 2-anilino-4-methyl-6-(1-propynyl)pyrimidine as slightly yellow crystals. The yield was 55.5%.

Provenance & Evidence