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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2166278Generated: November 3, 2026

4-Nitrobenzyl bromide → 4-Nitrobenzyl (2S,4R)-4-hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylate

https://huagongshe.com/reaction/2166278

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Nitrobenzyl bromideHCID 66011—
Reactanttrans-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)-L-prolineHCID 10566895—
Product4-Nitrobenzyl (2S,4R)-4-hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylateHCID 13644619—

Reaction Steps

In the same manner as described in Reference Example 1-2 but using 500 mg of trans-1-p-nitrobenzyloxycarbonyl-4-hydroxy-L-proline and 383 mg of p-nitrobenzyl bromide, trans-1-p-nitrobenzyloxycarbonyl-4-hydroxy-L-proline p-nitrobenzyl ester was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04943569
Source datasetuspto-grants-1990_07
ORD IDord-4bfa2e82bc514265aa6a4bf8ddb334ab
Source noteuspto-grants-1990_07