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In accordance with Flowchart A, 2,5-anhydro-D-mannose 1 is treated with acetyl chloride in anhydrous methanol at reflux, followed by neutralization with lead carbonate, giving 2,5-anhydro-D-mannose, dimethyl acetal 2, which is treated with sodium hydride in dimethylformamide, followed by reaction with benzyl bromide, giving 2,5-anhydro-3,4,6-tris-O-(phenylmethyl)--D-mannose, dimethyl acetal 3, which is treated with tetrafluoroboric acid in acetonitrile, giving 2,5-anhydro-3,4,6-tris-O-(phenylmethyl)-D-mannose 4. Compound 4 is reacted with a solution of lithiodiisopropylamine in tetrahydrofuran, and (difluoromethyl) phosphonic acid, diethyl ester at -75° C., giving a mixture of 3,6-anhydro-1-deoxy-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmehyl)-D-olvcero-D-galacto-heptitol and 2,5-anhydro-7-deoxy-7-(diethoxyphsophinyl)-7,7-difluoro-1,3,4-tris-O-(phenylmethyl)-D-glycero-Dmanno-heptitol, 5. The mixture 5 is reacted with N,N'-thiocarbonyldiimidazole in tetrahydrofuran, giving a mixture of 3,6-anhydro-1-deoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmethyl)-D-glycero-D-galacto-heptitol, 0-1H-imidazole-1-carbothioate and 2,5-anhydro-7-deoxy-7-(diethoxyphosphinyl)-7,7-difluoro-1,3,4-tris-O-(phenylmethyl)-D-glycero-D-manno-heptitol, 0-1H-imidazole-1-carbothioate 6. The mixture 6 is treated with n-tributyl stannous hydride and 2,2'-azobisisobutyronitrile in dry toluene under argon with heat, then purified by chromatography, giving 3,6-anhydro-1,2-dideoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmethyl)-D-manno-heptitol 7, which is treated first with boron trifluoride etherate in acetic anhydride at 0° C., giving acetate derivative 8, which is reacted with sodium ethoxide in ethanol under argon, giving 3,6-anhydro-1,2-dideoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5-bis-O-(phenylmethyl)-D-manno-heptitol 9. Compound 9 is treated with diphenyl chlorophosphate in pyridine under argon at ice bath temperature, giving 3,6-anhydro-1,2-dideoxy-1-(diethoxyphosphinyl)-1,1-difluoro-3,4-bis-O-(phenylmethyl)-D-manno-heptitol, 7-(diphenyl phosphate) 10 which is catalytically hydrogenated, giving 3,6-anhydro-1,2-dideoxy-1-(diethoxyphosphinyl)-1,1-difluoro-D-manno-heptitol, 7-(diphenyl phosphate) 11. Compound 11 is treated with trimethylsilyl bromide in deuterated chloroform under argon, giving 3,6-anhydro-1,2-dideoxy-1,1-difluoro-1-phosphono-D-manno-heptitol, 7-(diphenyl phosphate) 12 which is then catalytically hydrogenated giving the product 3,6-anhydro-1,2-dideoxy-1,1-difluoro-1-phosphono-D-manno-heptitol, 7-dihydrogen phosphate 13. ##STR10##

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